| Short Description : | Rabbit polyclonal JADE1 (210-509) antibody for use in IF, ICC and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | JADE1 |
| Gene ID: | 79960 |
| Uniprot ID: | JADE1_HUMAN |
| Immunogen Region: | 210-509 |
| Immunogen Sequence: | QSPDGEDGNEMVFCDKCNIC VHQACYGILKVPEGSWLCRT CALGVQPKCLLCPKKGGAMK PTRSGTKWVHVSCALWIPEV SIGSPEKMEPITKVSHIPSS RWALVCSLCNEKFGASIQCS VKNCRTAFHVTCAFDRGLEM KTILAENDEVKFKSYCPKHS SHRKPEESLGKGAAQENGAP ECSPRNPLEPFASLEQNREE AHRVSVRKQKLQQLEDEFYT FVNLLDVARALRLPEEVVD |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 210-509 of human JADE1 (NP_079176.2). |
| Tissue Specificity | Highly expressed in kidney. Also present in pancreas, liver and heart (at protein level). Down-regulated in renal cancer cells. |
| Function | Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity. Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac), regulating DNA replication initiation, regulating DNA replication initiation. May also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor. Negatively regulates canonical Wnt signaling.at least in part, cooperates with NPHP4 in this function. |
| Protein Name | Protein Jade-1Jade Family Phd Finger Protein 1Phd Finger Protein 17 |
| Database Links | Reactome: R-HSA-3214847 |
| Cellular Localisation | NucleusChromosomeCytoplasmCytoskeletonCilium Basal BodyLocalizes To The Ciliary Transition Zone |
| Alternative Antibody Names | Anti-Protein Jade-1 antibodyAnti-Jade Family Phd Finger Protein 1 antibodyAnti-Phd Finger Protein 17 antibodyAnti-JADE1 antibodyAnti-KIAA1807 antibodyAnti-PHF17 antibody |
Information sourced from Uniprot.org
