| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Iodotyrosine deiodinase 1 is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | IYD |
| Gene ID: | 389434 |
| Uniprot ID: | IYD1_HUMAN |
| Specificity: | This antibody detects endogenous levels of IYD at Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from human IYD |
| Function | Catalyzes the dehalogenation of halotyrosines such as 3-bromo-L-tyrosine, 3-chloro-L-tyrosine, 3-iodo-L-tyrosine and 3,5-diiodo-L-tyrosine. During thyroid hormone biosynthesis, facilitates iodide salvage by catalysing the oxidative NADPH-dependent deiodination of the halogenated by-products of thyroid hormone production, monoiodotyrosine (L-MIT) and diiodotyrosine (L-DIT). The scavanged iodide can then reenter the hormone-producing pathways. Acts more efficiently on 3-iodo-L-tyrosine than 3,5-diiodo-L-tyrosine. |
| Protein Name | Iodotyrosine Deiodinase 1Iyd-1Iodotyrosine Dehalogenase 1 |
| Database Links | Reactome: R-HSA-209968 |
| Cellular Localisation | Cell MembraneSingle-Pass Membrane ProteinCytoplasmic Vesicle Membrane |
| Alternative Antibody Names | Anti-Iodotyrosine Deiodinase 1 antibodyAnti-Iyd-1 antibodyAnti-Iodotyrosine Dehalogenase 1 antibodyAnti-IYD antibodyAnti-C6orf71 antibodyAnti-DEHAL1 antibody |
Information sourced from Uniprot.org