| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Involucrin (536-585 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:20000IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | IVL |
| Gene ID: | 3713 |
| Uniprot ID: | INVO_HUMAN |
| Immunogen Region: | 536-585 aa |
| Specificity: | Involucrin Polyclonal Antibody detects endogenous levels of Involucrin protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human Involucrin at the amino acid range 536-585 |
| Post Translational Modifications | Substrate of transglutaminase. Some glutamines and lysines are cross-linked to other involucrin molecules, to other proteins such as keratin, desmoplakin, periplakin and envoplakin, and to lipids like omega-hydroxyceramide. |
| Function | Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia. |
| Protein Name | Involucrin |
| Database Links | Reactome: R-HSA-6809371Reactome: R-HSA-9725554 |
| Cellular Localisation | CytoplasmConstituent Of The Scaffolding Of The Cornified Envelope |
| Alternative Antibody Names | Anti-Involucrin antibodyAnti-IVL antibody |
Information sourced from Uniprot.org