| Function | Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery. Acts as a guanine nucleotide exchange factor (GEF) for CDC42, and thereby stimulates actin nucleation mediated by WASL and the ARP2/3 complex. Plays a role in the assembly and maturation of clathrin-coated vesicles. Recruits FCHSD2 to clathrin-coated pits. Involved in endocytosis of activated EGFR, and probably also other growth factor receptors. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR).internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Promotes ubiquitination and subsequent degradation of EGFR, and thereby contributes to the down-regulation of EGFR-dependent signaling pathways. In chromaffin cells, required for normal exocytosis of catecholamines. Required for rapid replenishment of release-ready synaptic vesicles at presynaptic active zones. Inhibits ARHGAP31 activity toward RAC1. Isoform 1: Plays a role in synaptic vesicle endocytosis in brain neurons. |
| Protein Name | Intersectin-1Sh3 Domain-Containing Protein 1aSh3p17 |
| Database Links | Reactome: R-HSA-193648Reactome: R-HSA-3928662Reactome: R-HSA-416482Reactome: R-HSA-8856825Reactome: R-HSA-8856828Reactome: R-HSA-9013148Reactome: R-HSA-9013406Reactome: R-HSA-9013408 |
| Cellular Localisation | Endomembrane SystemSynapseSynaptosomeCell ProjectionLamellipodiumCell MembraneMembraneClathrin-Coated PitRecycling EndosomeEndosomeCytoplasmic VesicleColocalizes With Sgip1 At The Plasma Membrane In Structures Corresponding Most Probably To Clathrin-Coated PitsColocalizes With Rab13 On Cytoplasmic Vesicles That Are Most Likely Recycling EndosomesIsoform 2: CytoplasmNucleus EnvelopeShuttles Between The Cytoplasm And Nucleus In An Xpo1/Crm1-Dependent MannerIsoform 5: Endomembrane System |
| Alternative Antibody Names | Anti-Intersectin-1 antibodyAnti-Sh3 Domain-Containing Protein 1a antibodyAnti-Sh3p17 antibodyAnti-ITSN1 antibodyAnti-ITSN antibodyAnti-SH3D1A antibody |
Information sourced from Uniprot.org
