Anti-ITM2C antibody (1-51 aa) (STJ195090)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human ITM2C at the amino acid range 1-51
General Information
| Short Description | Rabbit polyclonal anti-Integral membrane protein 2C (1-51 aa) for use in WB and IHC in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC-P 1:50-300 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ITM2C |
| Gene ID | 81618 |
| Uniprot ID | ITM2C_HUMAN |
| Immunogen | Synthesized peptide derived from the human ITM2C at the amino acid range 1-51 |
| Immunogen Region | 1-51 aa |
| Specificity | This antibody detects endogenous levels of ITM2C at Human/Mouse/Rat |
Additional Info
| Post Translational Modifications | Type I membrane-bound, as well as soluble, furin has a pre-eminent role in ITM2C proteolytic processing. PCSK7 and PCSK5 may also be involved although to a lesser extent. The soluble form of PCSK7 is incapable of processing ITM2C. Fails to undergo shedding by ADAM10 and intramembrane cleavage by SPPL2B. |
| Function | Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation. |
| Protein Name | Integral Membrane Protein 2cCerebral Protein 14Transmembrane Protein Bri3 Cleaved Into - Ct-Bri3 |
| Database Links | |
| Cellular Localisation | Lysosome MembraneSingle-Pass Type Ii Membrane ProteinCell Membrane |
| Alternative Antibody Names | Anti-Integral Membrane Protein 2c antibodyAnti-Cerebral Protein 14 antibodyAnti-Transmembrane Protein Bri3 Cleaved Into - Ct-Bri3 antibodyAnti-ITM2C antibodyAnti-BRI3 antibodyAnti-hucep-14 antibodyAnti-NPD018 antibodyAnti-PSEC0047 antibody |
Information sourced from Uniprot.org