| Post Translational Modifications | Type I membrane-bound, as well as soluble, furin has a pre-eminent role in ITM2C proteolytic processing. PCSK7 and PCSK5 may also be involved although to a lesser extent. The soluble form of PCSK7 is incapable of processing ITM2C. Fails to undergo shedding by ADAM10 and intramembrane cleavage by SPPL2B. |
| Function | Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation. |
| Protein Name | Integral Membrane Protein 2cCerebral Protein 14Transmembrane Protein Bri3 Cleaved Into - Ct-Bri3 |
| Cellular Localisation | Lysosome MembraneSingle-Pass Type Ii Membrane ProteinCell Membrane |
| Alternative Antibody Names | Anti-Integral Membrane Protein 2c antibodyAnti-Cerebral Protein 14 antibodyAnti-Transmembrane Protein Bri3 Cleaved Into - Ct-Bri3 antibodyAnti-ITM2C antibodyAnti-BRI3 antibodyAnti-hucep-14 antibodyAnti-NPD018 antibodyAnti-PSEC0047 antibody |
Information sourced from Uniprot.org
