| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ITGAX |
| Gene ID: | 3687 |
| Uniprot ID: | ITAX_HUMAN |
| Immunogen Region: | 146-342 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 146-342 of ITGAX (NP_000878.2). |
| Immunogen Sequence: | PRQEQDIVFLIDGSGSISSR NFATMMNFVRAVISQFQRPS TQFSLMQFSNKFQTHFTFEE FRRSSNPLSLLASVHQLQGF TYTATAIQNVVHRLFHASYG ARRDAAKILIVITDGKKEGD SLDYKDVIPMADAAGIIRYA IGVGLAFQNRNSWKELNDIA SKPSQEHIFKVEDFDALKDI QNQLKEKIFAIEGTETT |
| Tissue Specificity | Predominantly expressed in monocytes and granulocytes. |
| Function | Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis. |
| Protein Name | Integrin Alpha-XCd11 Antigen-Like Family Member CLeu M5Leukocyte Adhesion Glycoprotein P150 -95 Alpha ChainLeukocyte Adhesion Receptor P150 -95Cd Antigen Cd11c |
| Database Links | Reactome: R-HSA-202733Reactome: R-HSA-216083Reactome: R-HSA-3000178Reactome: R-HSA-6785807Reactome: R-HSA-6798695 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Integrin Alpha-X antibodyAnti-Cd11 Antigen-Like Family Member C antibodyAnti-Leu M5 antibodyAnti-Leukocyte Adhesion Glycoprotein P150 -95 Alpha Chain antibodyAnti-Leukocyte Adhesion Receptor P150 -95 antibodyAnti-Cd Antigen Cd11c antibodyAnti-ITGAX antibodyAnti-CD11C antibody |
Information sourced from Uniprot.org
![C57BL/6 murine splenocytes were stained with Anti-CD11c antibody (STJA0000073) [Used at 0.2 µg/10<sup>6</sup> cells dilution] and Anti-Mouse MHC II (I-A/I-E) Monoclonal Antibody (FITC Conjugated). Splenocytes stained with Anti-Mouse MHC II (I-A/I-E) Monoclonal Antibody (FITC Conjugated) (Right) were used as control](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/144926/291595/STJA0000073_1__51247.1631205375.jpg?c=1 "C57BL/6 murine splenocytes were stained with Anti-CD11c antibody (STJA0000073) [Used at 0.2 µg/10<sup>6</sup> cells dilution] and Anti-Mouse MHC II (I-A/I-E) Monoclonal Antibody (FITC Conjugated). Splenocytes stained with Anti-Mouse MHC II (I-A/I-E) Monoclonal Antibody (FITC Conjugated) (Right) were used as control")
