| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S7MR |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 IHC-P:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ITGAL |
| Gene ID: | 3683 |
| Uniprot ID: | ITAL_HUMAN |
| Immunogen Region: | 1071-1170 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 1071-1170 of human CD11a/LFA-1A/ITGAL (P20701). |
| Immunogen Sequence: | NASLAQVVMKVDVVYEKQML YLYVLSGIGGLLLLLLIFIV LYKVGFFKRNLKEKMEAGRG VPNGIPAEDSEQLASGQEAG DPGCLKPLHEKDSESGGGKD |
| Tissue Specificity | Leukocytes. |
| Post Translational Modifications | In resting T-cells, up to 40% of surface ITGAL is constitutively phosphorylated. Phosphorylation causes conformational changes needed for ligand binding and is necessary for activation by some physiological agents. |
| Function | Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is a receptor for F11R. Integrin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15.the interaction is mediated by ITGAL. Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Acts as a platform at the immunological synapse to translate TCR engagement and density of the ITGAL ligand ICAM1 into graded adhesion. Required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis. Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages. |
| Protein Name | Integrin Alpha-L Cd11 Antigen-Like Family Member A Leukocyte Adhesion Glycoprotein Lfa-1 Alpha Chain Lfa-1a Leukocyte Function-Associated Molecule 1 Alpha Chain Cd Antigen Cd11a |
| Database Links | Reactome: R-HSA-198933 Reactome: R-HSA-202733 Reactome: R-HSA-216083 Reactome: R-HSA-6798695 Reactome: R-HSA-8949275 |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein Upon Antigen Recognition By The Tcr Is Recruited To Lipid Rafts |
| Alternative Antibody Names | Anti-Integrin Alpha-L antibody Anti-Cd11 Antigen-Like Family Member A antibody Anti-Leukocyte Adhesion Glycoprotein Lfa-1 Alpha Chain antibody Anti-Lfa-1a antibody Anti-Leukocyte Function-Associated Molecule 1 Alpha Chain antibody Anti-Cd Antigen Cd11a antibody Anti-ITGAL antibody Anti-CD11A antibody |
Information sourced from Uniprot.org