| Host: |
Rabbit |
| Applications: |
WB/IHC-P/IF/ICC/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:1000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ITGA2 |
| Gene ID: |
3673 |
| Uniprot ID: |
ITA2_HUMAN |
| Immunogen Region: |
30-162 |
| Specificity: |
A synthetic peptide corresponding to a sequence within amino acids 30-162 of human Integrin alpha 2 (ITGA2/CD49b) (NP_002194.2). |
| Immunogen Sequence: |
YNVGLPEAKIFSGPSSEQFG YAVQQFINPKGNWLLVGSPW SGFPENRMGDVYKCPVDLST ATCEKLNLQTSTSIPNVTEM KTNMSLGLILTRNMGTGGFL TCGPLWAQQCGNQYYTTGVC SDISPDFQLSASF |
| Function | Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human rotavirus A. (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human echoviruses 1 and 8. |
| Protein Name | Integrin Alpha-2Cd49 Antigen-Like Family Member BCollagen ReceptorPlatelet Membrane Glycoprotein IaGpiaVla-2 Subunit AlphaCd Antigen Cd49b |
| Database Links | Reactome: R-HSA-216083Reactome: R-HSA-3000157Reactome: R-HSA-3000170Reactome: R-HSA-3000178Reactome: R-HSA-447041Reactome: R-HSA-75892Reactome: R-HSA-8874081 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Integrin Alpha-2 antibodyAnti-Cd49 Antigen-Like Family Member B antibodyAnti-Collagen Receptor antibodyAnti-Platelet Membrane Glycoprotein Ia antibodyAnti-Gpia antibodyAnti-Vla-2 Subunit Alpha antibodyAnti-Cd Antigen Cd49b antibodyAnti-ITGA2 antibodyAnti-CD49B antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![C57BL/6 murine splenocytes were stained with Anti-Mouse CD49b Monoclonal Antibody (AF647 Conjugated)[Used at 0.2 µg/10<sup>6</sup> cells dilution] (filled gray histogram). Unstained splenocytes (empty black histogram) were used as control.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/145557/292215/STJA0000704_1__60020.1631206058.jpg?c=1 "C57BL/6 murine splenocytes were stained with Anti-Mouse CD49b Monoclonal Antibody (AF647 Conjugated)[Used at 0.2 µg/10<sup>6</sup> cells dilution] (filled gray histogram). Unstained splenocytes (empty black histogram) were used as control.")
![Mouse bone marrow cells were stained with Anti-CD49b antibody (STJA0000699) [Used at 0.02 µg/10<sup>6</sup> cells dilution] (filled gray histogram). Unstained bone marrow cells (blank black histogram) were used as control.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/145552/292210/STJA0000699_1__59246.1631206053.jpg?c=1 "Mouse bone marrow cells were stained with Anti-CD49b antibody (STJA0000699) [Used at 0.02 µg/10<sup>6</sup> cells dilution] (filled gray histogram). Unstained bone marrow cells (blank black histogram) were used as control.")
![Mouse bone marrow cells were stained with Anti-CD49b antibody (STJA0000698) [Used at 0.02 µg/10<sup>6</sup> cells dilution] (filled gray histogram). Unstained bone marrow cells (blank black histogram) were used as control.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/145551/292209/STJA0000698_1__44991.1631206052.jpg?c=1 "Mouse bone marrow cells were stained with Anti-CD49b antibody (STJA0000698) [Used at 0.02 µg/10<sup>6</sup> cells dilution] (filled gray histogram). Unstained bone marrow cells (blank black histogram) were used as control.")