Anti-ITGA2 antibody (30-162) (STJ29766)

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STJ29766
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Host: Rabbit
Applications: WB/IHC-P/IF/ICC/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:1000
IHC-P:1:50-1:200
IF/ICC:1:50-1:200
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ITGA2
Gene ID: 3673
Uniprot ID: ITA2_HUMAN
Immunogen Region: 30-162
Specificity: A synthetic peptide corresponding to a sequence within amino acids 30-162 of human Integrin alpha 2 (ITGA2/CD49b) (NP_002194.2).
Immunogen Sequence: YNVGLPEAKIFSGPSSEQFG YAVQQFINPKGNWLLVGSPW SGFPENRMGDVYKCPVDLST ATCEKLNLQTSTSIPNVTEM KTNMSLGLILTRNMGTGGFL TCGPLWAQQCGNQYYTTGVC SDISPDFQLSASF
Function Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human rotavirus A. (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human echoviruses 1 and 8.
Protein Name Integrin Alpha-2
Cd49 Antigen-Like Family Member B
Collagen Receptor
Platelet Membrane Glycoprotein Ia
Gpia
Vla-2 Subunit Alpha
Cd Antigen Cd49b
Database Links Reactome: R-HSA-216083
Reactome: R-HSA-3000157
Reactome: R-HSA-3000170
Reactome: R-HSA-3000178
Reactome: R-HSA-447041
Reactome: R-HSA-75892
Reactome: R-HSA-8874081
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-Integrin Alpha-2 antibody
Anti-Cd49 Antigen-Like Family Member B antibody
Anti-Collagen Receptor antibody
Anti-Platelet Membrane Glycoprotein Ia antibody
Anti-Gpia antibody
Anti-Vla-2 Subunit Alpha antibody
Anti-Cd Antigen Cd49b antibody
Anti-ITGA2 antibody
Anti-CD49B antibody

Information sourced from Uniprot.org