| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ISL1 (1-349) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ISL1 |
| Gene ID: |
3670 |
| Uniprot ID: |
ISL1_HUMAN |
| Immunogen Region: |
1-349 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-349 of human Islet1 (NP_002193.2). |
| Immunogen Sequence: |
MGDMGDPPKKKRLISLCVGC GNQIHDQYILRVSPDLEWHA ACLKCAECNQYLDESCTCFV RDGKTYCKRDYIRLYGIKCA KCSIGFSKNDFVMRARSKVY HIECFRCVACSRQLIPGDEF ALREDGLFCRADHDVVERAS LGAGDPLSPLHPARPLQMAA EPISARQPALRPHVHKQPEK TTRVRTVLNEKQLHTLRTCY AANPRPDALMKEQLVEMTGL SPRVIRVWFQNKRCKDKKR |
| Tissue Specificity | Expressed in subsets of neurons of the adrenal medulla and dorsal root ganglion, inner nuclear and ganglion cell layers in the retina, the pineal and some regions of the brain. |
| Post Translational Modifications | Ubiquitinated probably by WWP1 E3 ubiquitin ligase.ubiquitination is followed by protein degradation. Phosphorylated. |
| Function | DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Cooperates with the transcription factor POU4F2 to achieve maximal levels of expression of RGC target genes and RGC fate specification in the developing retina. Involved in the specification of motor neurons in cooperation with LHX3 and LDB1. Binds to insulin gene enhancer sequences. Essential for heart development. Marker of one progenitor cell population that give rise to the outflow tract, right ventricle, a subset of left ventricular cells, and a large number of atrial cells as well, its function is required for these progenitors to contribute to the heart. Controls the expression of FGF and BMP growth factors in this cell population and is required for proliferation and survival of cells within pharyngeal foregut endoderm and adjacent splanchnic mesoderm as well as for migration of cardiac progenitors into the heart. |
| Protein Name | Insulin Gene Enhancer Protein Isl-1Islet-1 |
| Database Links | Reactome: R-HSA-400511Reactome: R-HSA-9010553Reactome: R-HSA-9733709 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Insulin Gene Enhancer Protein Isl-1 antibodyAnti-Islet-1 antibodyAnti-ISL1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
