| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ISG20 (1-70) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ISG20 |
| Gene ID: |
3669 |
| Uniprot ID: |
ISG20_HUMAN |
| Immunogen Region: |
1-70 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-70 of human ISG20 (NP_002192.2). |
| Immunogen Sequence: |
MAGSREVVAMDCEMVGLGPH RESGLARCSLVNVHGAVLYD KFIRPEGEITDYRTRVSGVT PQHMVGATPF |
| Tissue Specificity | Highly expressed in peripheral blood leukocytes, spleen, thymus, colon and lung. Up regulated by E2 in estrogen receptor-positive breast cancer lines. |
| Function | Interferon-induced antiviral exoribonuclease that acts mainly on single-stranded RNA. Exhibits antiviral activity against RNA viruses including hepatitis C virus (HCV), hepatitis A virus (HAV) and yellow fever virus (YFV). Inhibition of several viruses such as chikungunya virus (CHIKV) does not involve the degradation of viral RNAs, but rather the inhibition of translation of viral proteins. Exerts a translational control over a large panel of non-self RNA substrates while sparing endogenous transcripts. This activity correlates with the protein's ability to localize in cytoplasmic processing bodies. May also act as master regulator of over hundred interferon stimulated genes leading to viral genome translation inhibition. May play additional roles in the maturation of snRNAs and rRNAs, and in ribosome biogenesis. |
| Protein Name | Interferon-Stimulated Gene 20 Kda ProteinEstrogen-Regulated Transcript 45 ProteinPromyelocytic Leukemia Nuclear Body-Associated Protein Isg20 |
| Database Links | Reactome: R-HSA-909733 |
| Cellular Localisation | NucleusNucleolusCytoplasmCajal BodyP-Body |
| Alternative Antibody Names | Anti-Interferon-Stimulated Gene 20 Kda Protein antibodyAnti-Estrogen-Regulated Transcript 45 Protein antibodyAnti-Promyelocytic Leukemia Nuclear Body-Associated Protein Isg20 antibodyAnti-ISG20 antibodyAnti-HEM45 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
