Anti-IRF6 antibody [R04-4B9] (STJA0036120)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human IRF6
General Information
| Short Description | Rabbit monoclonal anti-IRF6 for use in WB, IHC-P, ICC and IF in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ICC/IF |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R04-4B9 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Chromatography |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100IF 1:50-1:200 |
| Formulation | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | IRF6 |
| Gene ID | 3664 |
| Uniprot ID | IRF6_HUMAN |
| Immunogen | A synthesized peptide derived from human IRF6 |
Additional Info
| Tissue Specificity | Expressed in normal mammary epithelial cells. Expression is reduced or absent in breast carcinomas. |
| Post Translational Modifications | Phosphorylated. Phosphorylation status depends on the cell cycle and is a signal for ubiquitination and proteasome-mediated degradation. |
| Function | Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development. Plays a role in regulating mammary epithelial cell proliferation. May regulate WDR65 transcription. |
| Protein Name | Interferon Regulatory Factor 6Irf-6 |
| Database Links | Reactome: R-HSA-877300Reactome: R-HSA-909733 |
| Cellular Localisation | NucleusCytoplasmTranslocates To Nucleus In Response To An Activating Signal |
| Alternative Antibody Names | Anti-Interferon Regulatory Factor 6 antibodyAnti-Irf-6 antibodyAnti-IRF6 antibody |
Information sourced from Uniprot.org