• Western blot analysis of the lysates from HUVECcells using IRAK3 antibody.
  • Western blot analysis of lysates from K562 cells, using IRAK3 Antibody. The lane on the right is blocked with the synthesized peptide.
  • Immunofluorescence analysis of HeLa cells, using IRAK3 Antibody. The picture on the right is blocked with the synthesized peptide.
  • Immunohistochemistry analysis of paraffin-embedded human brain, using IRAK3 Antibody. The picture on the right is blocked with the synthesized peptide.
  • Western blot analysis of LOVO cells using IRAK-M Polyclonal Antibody

Anti-IRAK3 antibody (491-540 aa) (STJ93758)

SKU:
STJ93758

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Interleukin-1 receptor-associated kinase 3 (491-540 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: IRAK3
Gene ID: 11213
Uniprot ID: IRAK3_HUMAN
Immunogen Region: 491-540 aa
Specificity: IRAK-M Polyclonal Antibody detects endogenous levels of IRAK-M protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human IRAK3 at the amino acid range 491-540
Function Putative inactive protein kinase which regulates signaling downstream of immune receptors including IL1R and Toll-like receptors. Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex. Upon IL33-induced lung inflammation, positively regulates expression of IL6, CSF3, CXCL2 and CCL5 mRNAs in dendritic cells.
Protein Name Interleukin-1 Receptor-Associated Kinase 3
Irak-3
Il-1 Receptor-Associated Kinase M
Irak-M
Inactive Il-1 Receptor-Associated Kinase 3
Database Links Reactome: R-HSA-166058
Reactome: R-HSA-9020702
Cellular Localisation Cytoplasm
Nucleus
In Dendritic Cells
Translocates Into The Nucleus Upon Il33 Stimulation
Alternative Antibody Names Anti-Interleukin-1 Receptor-Associated Kinase 3 antibody
Anti-Irak-3 antibody
Anti-Il-1 Receptor-Associated Kinase M antibody
Anti-Irak-M antibody
Anti-Inactive Il-1 Receptor-Associated Kinase 3 antibody
Anti-IRAK3 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance