| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Interleukin-1 receptor-associated kinase 3 (491-540 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | IRAK3 |
| Gene ID: | 11213 |
| Uniprot ID: | IRAK3_HUMAN |
| Immunogen Region: | 491-540 aa |
| Specificity: | IRAK-M Polyclonal Antibody detects endogenous levels of IRAK-M protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human IRAK3 at the amino acid range 491-540 |
| Function | Putative inactive protein kinase which regulates signaling downstream of immune receptors including IL1R and Toll-like receptors. Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex. Upon IL33-induced lung inflammation, positively regulates expression of IL6, CSF3, CXCL2 and CCL5 mRNAs in dendritic cells. |
| Protein Name | Interleukin-1 Receptor-Associated Kinase 3Irak-3Il-1 Receptor-Associated Kinase MIrak-MInactive Il-1 Receptor-Associated Kinase 3 |
| Database Links | Reactome: R-HSA-166058Reactome: R-HSA-9020702 |
| Cellular Localisation | CytoplasmNucleusIn Dendritic CellsTranslocates Into The Nucleus Upon Il33 Stimulation |
| Alternative Antibody Names | Anti-Interleukin-1 Receptor-Associated Kinase 3 antibodyAnti-Irak-3 antibodyAnti-Il-1 Receptor-Associated Kinase M antibodyAnti-Irak-M antibodyAnti-Inactive Il-1 Receptor-Associated Kinase 3 antibodyAnti-IRAK3 antibody |
Information sourced from Uniprot.org
