| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-IPO11 (776-975) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
IPO11 |
| Gene ID: |
51194 |
| Uniprot ID: |
IPO11_HUMAN |
| Immunogen Region: |
776-975 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 776-975 of human IPO11 (NP_057422.3). |
| Immunogen Sequence: |
KGIIEGERYPVVMSTYLGVM GRVLLQNTSFFSSLLNEMAH KFNQEMDQLLGNMIEMWVDR MDNITQPERRKLSALALLSL LPSDNSVIQDKFCGIINISV EGLHDVMTEDPETGTYKDCM LMSHLEEPKVTEDEEPPTEQ DKRKKMLALKDPVHTVSLQQ FIYEKLKAQQEMLGEQGFQS LMETVDTEIVTQLQEFLQGF |
| Function | Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of UBE2E3, and of RPL12. |
| Protein Name | Importin-11Imp11Ran-Binding Protein 11Ranbp11 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Importin-11 antibodyAnti-Imp11 antibodyAnti-Ran-Binding Protein 11 antibodyAnti-Ranbp11 antibodyAnti-IPO11 antibodyAnti-RANBP11 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
