| Short Description : | Rabbit polyclonal IPO11 (776-975) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | IPO11 |
| Gene ID: | 51194 |
| Uniprot ID: | IPO11_HUMAN |
| Immunogen Region: | 776-975 |
| Immunogen Sequence: | KGIIEGERYPVVMSTYLGVM GRVLLQNTSFFSSLLNEMAH KFNQEMDQLLGNMIEMWVDR MDNITQPERRKLSALALLSL LPSDNSVIQDKFCGIINISV EGLHDVMTEDPETGTYKDCM LMSHLEEPKVTEDEEPPTEQ DKRKKMLALKDPVHTVSLQQ FIYEKLKAQQEMLGEQGFQS LMETVDTEIVTQLQEFLQGF |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 776-975 of human IPO11 (NP_057422.3). |
| Function | Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of UBE2E3, and of RPL12. |
| Protein Name | Importin-11Imp11Ran-Binding Protein 11Ranbp11 |
| Database Links | |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Importin-11 antibodyAnti-Imp11 antibodyAnti-Ran-Binding Protein 11 antibodyAnti-Ranbp11 antibodyAnti-IPO11 antibodyAnti-RANBP11 antibody |
Information sourced from Uniprot.org
