| Function | Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of UBE2E3, and of RPL12. |
| Protein Name | Importin-11Imp11Ran-Binding Protein 11Ranbp11 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Importin-11 antibodyAnti-Imp11 antibodyAnti-Ran-Binding Protein 11 antibodyAnti-Ranbp11 antibodyAnti-IPO11 antibodyAnti-RANBP11 antibody |
Information sourced from Uniprot.org
