| Function | Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA. The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs). Within the integrator complex, INTS8 is required for the recruitment of protein phosphatase 2A (PP2A) to transcription pause-release checkpoint. |
| Protein Name | Integrator Complex Subunit 8Int8Protein Kaonashi-1 |
| Database Links | Reactome: R-HSA-6807505 |
| Cellular Localisation | NucleusChromosomeAssociates With Chromatin And Transcription Pause-Release Checkpoint |
| Alternative Antibody Names | Anti-Integrator Complex Subunit 8 antibodyAnti-Int8 antibodyAnti-Protein Kaonashi-1 antibodyAnti-INTS8 antibodyAnti-C8orf52 antibody |
Information sourced from Uniprot.org
