| Function | Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA. The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs). Within the integrator complex, INTS6 acts as a molecular adapter that promotes assembly of protein phosphatase 2A (PP2A) subunits to the integrator core complex, promoting recruitment of PP2A to transcription pause-release checkpoint. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex. May have a tumor suppressor role.an ectopic expression suppressing tumor cell growth. |
| Protein Name | Integrator Complex Subunit 6Int6Dbi-1Protein Deleted In Cancer 1Dice1 |
| Database Links | Reactome: R-HSA-6807505 |
| Cellular Localisation | NucleusChromosomeAssociates With Chromatin And Transcription Pause-Release Checkpoint |
| Alternative Antibody Names | Anti-Integrator Complex Subunit 6 antibodyAnti-Int6 antibodyAnti-Dbi-1 antibodyAnti-Protein Deleted In Cancer 1 antibodyAnti-Dice1 antibodyAnti-INTS6 antibodyAnti-DBI1 antibodyAnti-DDX26 antibodyAnti-DDX26A antibody |
Information sourced from Uniprot.org
