| Post Translational Modifications | Dephosphorylated at Ser-128 by the PNUTS-PP1 complex, promoting RNA polymerase II transcription pause-release. |
| Function | Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA. The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex. |
| Protein Name | Integrator Complex Subunit 12Int12Phd Finger Protein 22 |
| Database Links | Reactome: R-HSA-6807505 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Integrator Complex Subunit 12 antibodyAnti-Int12 antibodyAnti-Phd Finger Protein 22 antibodyAnti-INTS12 antibodyAnti-PHF22 antibodyAnti-SBBI22 antibody |
Information sourced from Uniprot.org
