| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: | Monoclonal |
| Clone ID: | SRM |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: | INTS12 |
| Gene ID: | 57117 |
| Uniprot ID: | INT12_HUMAN |
| Immunogen Region: | 1-230 aa |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human INTS12 (NP_065128.2). |
| Immunogen Sequence: | MAATVNLELDPIFLKALGFL HSKSKDSAEKLKALLDESLA RGIDSSYRPSQKDVEPPKIS STKNISIKQEPKISSSLPSG NNNGKVLTTEKVKKEAEKRP ADKMKSDITEGVDIPKKPRL EKPETQSSPITVQSSKDLPM ADLSSFEETSADDFAMEMGL ACVVCRQMMVASGNQLVECQ ECHNLYHRDCHKPQVTDKEA NDPRLVWYCARCTRQMKRMA QKTQKPPQKP |
| Function | Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex. |
| Protein Name | Integrator Complex Subunit 12 Int12 Phd Finger Protein 22 |
| Database Links | Reactome: R-HSA-6807505 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Integrator Complex Subunit 12 antibody Anti-Int12 antibody Anti-Phd Finger Protein 22 antibody Anti-INTS12 antibody Anti-PHF22 antibody Anti-SBBI22 antibody |
Information sourced from Uniprot.org