Anti-Interleukin-1ra3 antibody [2D11] (STJ16100660)

SKU:
STJ16100660-1

£632.50
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Host: Mouse
Applications: IHC-F/ELISA/WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-Interleukin-1ra3 is suitable for use in Immunohistochemistry, ELISA and Western Blot research applications.
Clonality: Monoclonal
Clone ID: 2D11
Conjugation: Unconjugated
Isotype: IgG1
Formulation: PBS with 0.1% BSA and 0.02% sodium azide
Concentration: 100 ug/mL
Storage Instruction: Store at 2-8°C upon receipt.
Background The antibody reacts specificly with Human IL-1ra3. IL-1ra3 belongs to the IL-1 system which includes two agonists (IL-1alpha and IL-1beta) , converting enzymes, antagonists, two receptors (IL-1 R I and IL-1 R II) and the IL-1 receptor accessory protein. Three molecular isoforms of the IL-1 receptor antagonist (IL-1ra) have been identified and cloned. Secreted IL-1ra (sIL-1ra or IL-1ra1) contains a classical leader peptide giving a released mature protein. Two intracellular isoforms, icIL-1ra type I (IL-1ra2) and icIL-1 ra type II (IL-1ra3) , have no leader sequence, thus predicting that these proteins remain intracellular. IL-1ra3 may represent a reservoir of IL-1 inhibitors, released upon cell death, whose function is to limit the pro-inflammatory action of cell debris. Studies have shown that IL-1ra3 is expressed by various cell types upon exposure to inflammatory signals but most prominently by mononuclear phagocytes and keratinocytes.

Information sourced from Uniprot.org

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