Anti-Integrin beta 4 (ITGB4/CD104) antibody [SRM13437] (STJ11108167)

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STJ11108167
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Host: Rabbit
Applications: IF-P/IHC-P/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Monoclonal
Clone ID : SRM13437
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS containing 50% Glycerol and 0.05% BSA, preserved with proclin300 or Sodium Azide (as specified on the Certificate of Analysis) , pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: IF-P, 1:50-1:200
IHC-P, 1:500-1:1000
ELISA, Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ITGB4
Gene ID: 3691
Uniprot ID: ITB4_HUMAN
Immunogen: Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Immunogen Sequence: Human
Post Translational Modifications Palmitoylated by DHHC3 at several cysteines of the membrane-proximal region, enhancing stability and cell surface expression. Palmitoylation also promotes secondary association with tertaspanins.
Function Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling. ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling.
Protein Name Integrin Beta-4
Gp150
Cd Antigen Cd104
Database Links Reactome: R-HSA-2022090
Reactome: R-HSA-3000157
Reactome: R-HSA-3000170
Reactome: R-HSA-446107
Reactome: R-HSA-9725554
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Lipid-Anchor
Cell Junction
Hemidesmosome
Colocalizes With Dst At The Leading Edge Of Migrating Keratinocytes
Alternative Antibody Names Anti-Integrin Beta-4 antibody
Anti-Gp150 antibody
Anti-Cd Antigen Cd104 antibody
Anti-ITGB4 antibody

Information sourced from Uniprot.org

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