Anti-Integrin alpha 9 antibody [R08-8J9] (STJA0037022)

SKU:
STJA0037022
£133.50 - £281.50
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Host: Rabbit
Applications: WB/IHC-P
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit monoclonal anti-Integrin alpha 9 for use in WB and IHC-P in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents.
Clonality : Monoclonal
Clone ID : R08-8J9
Conjugation: Unconjugated
Isotype: IgG
Formulation: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification: Affinity Chromatography
Dilution Range: WB 1:500-1:1000
IHC 1:50-1:100
Storage Instruction: Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles.
Gene Symbol: ITGA9
Gene ID: 3680
Uniprot ID: ITA9_HUMAN
Immunogen: A synthesized peptide derived from human Integrin alpha 9
Tissue Specificity Expressed in vascular smooth muscle cells (at protein level). Expressed in the airway epithelium (at protein level).
Function Integrin alpha-9/beta-1 (ITGA9:ITGB1) is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. ITGA9:ITGB1 may play a crucial role in SVEP1/polydom-mediated myoblast cell adhesion. Integrin ITGA9:ITGB1 represses PRKCA-mediated L-type voltage-gated channel Ca(2+) influx and ROCK-mediated calcium sensitivity in vascular smooth muscle cells via its interaction with SVEP1, thereby inhibiting vasocontraction.
Protein Name Integrin Alpha-9
Integrin Alpha-Rlc
Database Links Reactome: R-HSA-216083
Reactome: R-HSA-3000178
Reactome: R-HSA-445144
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-Integrin Alpha-9 antibody
Anti-Integrin Alpha-Rlc antibody
Anti-ITGA9 antibody

Information sourced from Uniprot.org

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