| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | INSRR |
| Gene ID: | 3645 |
| Uniprot ID: | INSRR_HUMAN |
| Immunogen Region: | 747-921 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 747-921 of human INSRR (NP_055030.1). |
| Immunogen Sequence: | AAGPLRLGGNSSDFEIQEDK VPRERAVLSGLRHFTEYRID IHACNHAAHTVGCSAATFVF ARTMPHREADGIPGKVAWEA SSKNSVLLRWLEPPDPNGLI LKYEIKYRRLGEEATVLCVS RLRYAKFGGVHLALLPPGNY SARVRATSLAGNGSWTDSVA FYILGPEEEDAGGLH |
| Post Translational Modifications | Autophosphorylated on tyrosine residues between pH 7.9 and pH 10.5. |
| Function | Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB. |
| Protein Name | Insulin Receptor-Related ProteinIrrIr-Related Receptor Cleaved Into - Insulin Receptor-Related Protein Alpha Chain - Insulin Receptor-Related Protein Beta Chain |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Insulin Receptor-Related Protein antibodyAnti-Irr antibodyAnti-Ir-Related Receptor Cleaved Into - Insulin Receptor-Related Protein Alpha Chain - Insulin Receptor-Related Protein Beta Chain antibodyAnti-INSRR antibodyAnti-IRR antibody |
Information sourced from Uniprot.org
