| Host: | Rabbit |
| Applications: | IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | IHC-P:1:50-1:100IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | INSL3 |
| Gene ID: | 3640 |
| Uniprot ID: | INSL3_HUMAN |
| Immunogen Region: | 1-131 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-131 of human INSL3 (NP_005534.2). |
| Immunogen Sequence: | MDPRLPAWALVLLGPALVFA LGPAPTPEMREKLCGHHFVR ALVRVCGGPRWSTEARRPAT GGDRELLQWLERRHLLHGLV ADSNLTLGPGLQPLPQTSHH HRHHRAAATNPARYCCLSGC TQQDLLTLCPY |
| Tissue Specificity | Expressed in prenatal and postnatal Leydig cells. Found as well in the corpus luteum, trophoblast, fetal membranes and breast. |
| Function | Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor. |
| Protein Name | Insulin-Like 3Leydig Insulin-Like PeptideLey-I-LRelaxin-Like Factor Cleaved Into - Insulin-Like 3 B Chain - Insulin-Like 3 A Chain |
| Database Links | Reactome: R-HSA-418555Reactome: R-HSA-444821 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Insulin-Like 3 antibodyAnti-Leydig Insulin-Like Peptide antibodyAnti-Ley-I-L antibodyAnti-Relaxin-Like Factor Cleaved Into - Insulin-Like 3 B Chain - Insulin-Like 3 A Chain antibodyAnti-INSL3 antibodyAnti-RLF antibodyAnti-RLNL antibody |
Information sourced from Uniprot.org