Western blot analysis of lysates from HCT116 cells, primary antibody was diluted at 1:1000, 4°C over night

Anti-INPP5B antibody (292-342 aa) (STJ195512)

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STJ195512
£48.00 - £252.00
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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-Type II inositol 1, 4, 5-trisphosphate 5-phosphatase (292-342 aa) is suitable for use in Western Blot research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: INPP5B
Gene ID: 3633
Uniprot ID: I5P2_HUMAN
Immunogen Region: 292-342 aa
Specificity: This antibody detects endogenous levels of I5P2 at Human/Mouse
Immunogen: Synthesized peptide derived from the human I5P2 at the amino acid range 292-342
Post Translational Modifications Isoprenylation at Cys-990 may be required for localization at the membrane. May be proteolytically cleaved after Lys-320 as inferred from N-terminal protein sequence of the 75 kda form.
Function Hydrolyzes phosphatidylinositol 4,5-bisphosphate (PtIns(4,5)P2) and the signaling molecule phosphatidylinositol 1,4,5-trisphosphate (PtIns(1,4,5)P3), and thereby modulates cellular signaling events.
Protein Name Type Ii Inositol 1 -4 -5-Trisphosphate 5-Phosphatase
75 Kda Inositol Polyphosphate-5-Phosphatase
Phosphoinositide 5-Phosphatase
5ptase
Database Links Reactome: R-HSA-1855183
Reactome: R-HSA-1855204
Cellular Localisation Cytoplasm
Cytosol
Endoplasmic Reticulum-Golgi Intermediate Compartment
Early Endosome Membrane
Membrane
Peripheral Membrane Protein
Cytoplasmic Side
Cytoplasmic Vesicle
Phagosome Membrane
Golgi Apparatus
Alternative Antibody Names Anti-Type Ii Inositol 1 -4 -5-Trisphosphate 5-Phosphatase antibody
Anti-75 Kda Inositol Polyphosphate-5-Phosphatase antibody
Anti-Phosphoinositide 5-Phosphatase antibody
Anti-5ptase antibody
Anti-INPP5B antibody
Anti-OCRL2 antibody

Information sourced from Uniprot.org

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