| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | INPP5A |
| Gene ID: | 3632 |
| Uniprot ID: | I5P1_HUMAN |
| Immunogen Region: | 10-200 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 10-200 of human INPP5A (NP_005530.3). |
| Immunogen Sequence: | TAVLLVTANVGSLFDDPENL QKNWLREFYQVVHTHKPHFM ALHCQEFGGKNYEASMSHVD KFVKELLSSDAMKEYNRARV YLDENYKSQEHFTALGSFYF LHESLKNIYQFDFKAKKYRK VAGKEIYSDTLESTPMLEKE KFPQDYFPECKWSRKGFIRT RWCIADCAFDLVNIHLFHDA SNLVAWETSPS |
| Tissue Specificity | Predominantly expressed in heart, brain, and skeletal muscle. In brain.high level in Purkinje cells. |
| Post Translational Modifications | Isoprenylation at Cys-409 is required for localization at the membrane. |
| Function | Phosphatase that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate, and inositol 1,3,4,5-tetrasphosphate to inositol 1,3,4-trisphosphate. Plays a crucial role in the survival of cerebellar Purkinje cells. |
| Protein Name | Inositol Polyphosphate-5-Phosphatase A 43 Kda Inositol Polyphosphate 5-Phosphatase Type I Inositol 1 -4 -5-Trisphosphate 5-Phosphatase 5ptase |
| Database Links | Reactome: R-HSA-1855183 |
| Cellular Localisation | Cell Membrane Lipid-Anchor Cell Projection Dendrite |
| Alternative Antibody Names | Anti-Inositol Polyphosphate-5-Phosphatase A antibody Anti-43 Kda Inositol Polyphosphate 5-Phosphatase antibody Anti-Type I Inositol 1 -4 -5-Trisphosphate 5-Phosphatase antibody Anti-5ptase antibody Anti-INPP5A antibody Anti-5PTASE antibody |
Information sourced from Uniprot.org