| Tissue Specificity | Widely expressed with highest levels occurring in the skeletal muscle and heart. |
| Function | Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-trisphosphate. Plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3,4-bisphosphate in membrane ruffles. The lipid phosphatase activity is critical for tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. |
| Protein Name | Inositol Polyphosphate 4-Phosphatase Type IiType Ii Inositol 3 -4-Bisphosphate 4-Phosphatase |
| Database Links | Reactome: R-HSA-1660499Reactome: R-HSA-1660516Reactome: R-HSA-1855183 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Inositol Polyphosphate 4-Phosphatase Type Ii antibodyAnti-Type Ii Inositol 3 -4-Bisphosphate 4-Phosphatase antibodyAnti-INPP4B antibody |
Information sourced from Uniprot.org
