| Host: | Goat |
| Applications: | Pep-ELISA/WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Goat polyclonal antibody anti-IMPDH2 (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:8000. WB: Approx. 60kDa band observed in Human Skeletal Muscle lysates (calculated MW of 55.8kDa according to NP_000875.2). Recommended concentration: 1-3µg/ml. |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | IMPDH2 |
| Gene ID: | 3615 |
| Uniprot ID: | IMDH2_HUMAN |
| Immunogen Region: | Internal |
| Accession Number: | NP_000875.2 |
| Immunogen Sequence: | KEEEHDCFLEEI |
| Post Translational Modifications | Ubiquitinated leading to its degradation by the proteasome. The N-terminus is blocked. Acetylated by CLOCK in a circadian manner. |
| Function | Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. |
| Protein Name | Inosine-5'-Monophosphate Dehydrogenase 2 Imp Dehydrogenase 2 Impd 2 Impdh 2 Inosine-5'-Monophosphate Dehydrogenase Type Ii Imp Dehydrogenase Ii Impdh-Ii |
| Database Links | Reactome: R-HSA-6798695 Reactome: R-HSA-73817 Reactome: R-HSA-9679191 Reactome: R-HSA-9748787 |
| Cellular Localisation | Cytoplasm Nucleus Cytosol Can Form Fiber-Like Subcellular Structures Termed 'Cytoophidia' In Response To Intracellular Guanine-Nucleotide Depletion |
| Alternative Antibody Names | Anti-Inosine-5'-Monophosphate Dehydrogenase 2 antibody Anti-Imp Dehydrogenase 2 antibody Anti-Impd 2 antibody Anti-Impdh 2 antibody Anti-Inosine-5'-Monophosphate Dehydrogenase Type Ii antibody Anti-Imp Dehydrogenase Ii antibody Anti-Impdh-Ii antibody Anti-IMPDH2 antibody Anti-IMPD2 antibody |
Information sourced from Uniprot.org
