| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
IMPACT |
| Gene ID: |
55364 |
| Uniprot ID: |
IMPCT_HUMAN |
| Immunogen Region: |
1-140 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human IMPACT (NP_060909.1). |
| Immunogen Sequence: |
MAEGDAGSDQRQNEEIEAMA AIYGEEWCVIDDCAKIFCIR ISDDIDDPKWTLCLQVMLPN EYPGTAPPIYQLNAPWLKGQ ERADLSNSLEEIYIQNIGES ILYLWVEKIRDVLIQKSQMT EPGPDVKKKTEEEDVECEDD |
| Tissue Specificity | Widely expressed. Expressed at high level in brain. |
| Function | Translational regulator that ensures constant high levels of translation upon a variety of stress conditions, such as amino acid starvation, UV-C irradiation, proteasome inhibitor treatment and glucose deprivation. Plays a role as a negative regulator of the EIF2AK4/GCN2 kinase activity.impairs GCN1-mediated EIF2AK4/GCN2 activation, and hence EIF2AK4/GCN2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis. May be required to regulate translation in specific neuronal cells under amino acid starvation conditions by preventing GCN2 activation and therefore ATF4 synthesis. Through its inhibitory action on EIF2AK4/GCN2, plays a role in differentiation of neuronal cells by stimulating neurite outgrowth. |
| Protein Name | Protein ImpactImprinted And Ancient Gene Protein Homolog |
| Database Links | Reactome: R-HSA-9633012 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Protein Impact antibodyAnti-Imprinted And Ancient Gene Protein Homolog antibodyAnti-IMPACT antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
