| Short Description : | Goat polyclonal antibody anti-IL3RA/CD123 (Internal) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Applications: | Pep-ELISA/WB/IHC |
| Host: | Goat |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 0.5 mg/mL |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:128000.WB: Approx 43kDa band observed in lysates of cell lines Jurkat and Molt4 (calculated MW of 43.3kDa according to NP_002174.1). Recommended concentration: 1-3µg/ml. Primary incubation was 1 |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | IL3RA |
| Gene ID: | 3563 |
| Uniprot ID: | IL3RA_HUMAN |
| Accession Number: | NP_002174.1; NP_001254642.1 |
| Immunogen Region: | Internal |
| Immunogen Sequence: | RQQYECLHYKTD |
| Specificity: | This antibody is expected to recognize both reported isoforms (NP_002174.1; NP_001254642.1). |
| Function | Cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes and B-lymphocytes that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Ligand stimulation rapidly induces hetrodimerization with IL3RB, phosphorylation and enzyme activity of effector proteins such as JAK2 and PI3K that play a role in signaling cell proliferation and differentiation. Activation of JAK2 leads to STAT5-mediated transcriptional program. |
| Protein Name | Interleukin-3 Receptor Subunit AlphaIl-3 Receptor Subunit AlphaIl-3r Subunit AlphaIl-3r-AlphaIl-3raCd Antigen Cd123 |
| Database Links | Reactome: R-HSA-512988Reactome: R-HSA-5673001Reactome: R-HSA-912526 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Interleukin-3 Receptor Subunit Alpha antibodyAnti-Il-3 Receptor Subunit Alpha antibodyAnti-Il-3r Subunit Alpha antibodyAnti-Il-3r-Alpha antibodyAnti-Il-3ra antibodyAnti-Cd Antigen Cd123 antibodyAnti-IL3RA antibodyAnti-IL3R antibody |
Information sourced from Uniprot.org
