| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-IL36G (1-169) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
IL36G |
| Gene ID: |
56300 |
| Uniprot ID: |
IL36G_HUMAN |
| Immunogen Region: |
1-169 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-169 of human IL36G (NP_062564.1). |
| Immunogen Sequence: |
MRGTPGDADGGGRAVYQSMC KPITGTINDLNQQVWTLQGQ NLVAVPRSDSVTPVTVAVIT CKYPEALEQGRGDPIYLGIQ NPEMCLYCEKVGEQPTLQLK EQKIMDLYGQPEPVKPFLFY RAKTGRTSTLESVAFPDWFI ASSKRDQPIILTSELGKSYN TAFELNIND |
| Tissue Specificity | Highly expressed in tissues containing epithelial cells: skin, lung, stomach and esophagus. Expressed in bronchial epithelial. In skin is expressed only in keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Up-regulated in lesional psoriasis skin. Expressed in monocyte-derived dendritic cells and M1 macrophages. |
| Post Translational Modifications | N-terminal truncation leads to a dramatic enhancement of its activity (>1000-fold). Proteolytically cleaved by cathepsin CTSG. |
| Function | Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response.similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1.also stimulates its own expression and that of the prototypic cutaneous pro-inflammatory parameters TNF-alpha, S100A7/psoriasin and inducible NOS. May play a role in pro-inflammatory responses during particular neutrophilic airway inflammation: activates mitogen-activated protein kinases and NF-kappa B in primary lung fibroblasts, and stimulates the expression of IL-8 and CXCL3 and Th17 chemokine CCL20 in lung fibroblasts. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. |
| Protein Name | Interleukin-36 GammaIl-1-Related Protein 2Il-1rp2Interleukin-1 EpsilonIl-1 EpsilonInterleukin-1 Family Member 9Il-1f9Interleukin-1 Homolog 1Il-1h1 |
| Database Links | Reactome: R-HSA-9014826 |
| Cellular Localisation | CytoplasmSecretedThe Secretion Is Dependent On Protein Unfolding And Facilitated By The Cargo Receptor Tmed10It Results In Protein Translocation From The Cytoplasm Into The Ergic (Endoplasmic Reticulum-Golgi Intermediate Compartment) Followed By Vesicle Entry And Secretion |
| Alternative Antibody Names | Anti-Interleukin-36 Gamma antibodyAnti-Il-1-Related Protein 2 antibodyAnti-Il-1rp2 antibodyAnti-Interleukin-1 Epsilon antibodyAnti-Il-1 Epsilon antibodyAnti-Interleukin-1 Family Member 9 antibodyAnti-Il-1f9 antibodyAnti-Interleukin-1 Homolog 1 antibodyAnti-Il-1h1 antibodyAnti-IL36G antibodyAnti-IL1E antibodyAnti-IL1F9 antibodyAnti-IL1H1 antibodyAnti-IL1RP2 antibodyAnti-UNQ2456 antibodyAnti-PRO5737 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
