• Immunohistochemical analysis of paraffin-embedded human-lung, antibody was diluted at 1:100
  • Immunohistochemical analysis of paraffin-embedded human-lung, antibody was diluted at 1:100
  • Western blot analysis of HepG2 cells using IL-1F8 Polyclonal Antibody.. Secondary antibody was diluted at 1:20000

Anti-IL36B antibody (111-160 aa) (STJ96877)

SKU:
STJ96877

Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Interleukin-36 beta (111-160 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC-P 1:100-1:300
ELISA 1:20000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: IL36B
Gene ID: 27177
Uniprot ID: IL36B_HUMAN
Immunogen Region: 111-160 aa
Specificity: IL-1F8 Polyclonal Antibody detects endogenous levels of IL-1F8 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the C-terminal region of human IL36B at the amino acid range 111-160
Post Translational Modifications N-terminal truncation leads to a dramatic enhancement of its activity (>1000-fold).
Function Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response.similar to the IL-1 system with which it shares the coreceptor IL1RAP. Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensins 4 and 103 as well as a number of matrix metalloproteases. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of pro-inflammatory cytokines such as TNF-alpha, IL-8 and IL-6.
Protein Name Interleukin-36 Beta
Fil1 Eta
Interleukin-1 Eta
Il-1 Eta
Interleukin-1 Family Member 8
Il-1f8
Interleukin-1 Homolog 2
Il-1h2
Database Links Reactome: R-HSA-9014826
Cellular Localisation Cytoplasm
Secreted
The Secretion Is Dependent On Protein Unfolding And Facilitated By The Cargo Receptor Tmed10
It Results In Protein Translocation From The Cytoplasm Into The Ergic (Endoplasmic Reticulum-Golgi Intermediate Compartment) Followed By Vesicle Entry And Secretion
Alternative Antibody Names Anti-Interleukin-36 Beta antibody
Anti-Fil1 Eta antibody
Anti-Interleukin-1 Eta antibody
Anti-Il-1 Eta antibody
Anti-Interleukin-1 Family Member 8 antibody
Anti-Il-1f8 antibody
Anti-Interleukin-1 Homolog 2 antibody
Anti-Il-1h2 antibody
Anti-IL36B antibody
Anti-IL1F8 antibody
Anti-IL1H2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance