| Host: | Mouse |
| Applications: | WB/IF/FC/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-Interleukin-34 is suitable for use in Western Blot, Immunofluorescence, Flow Cytometry and ELISA research applications. |
| Clonality : | Monoclonal |
| Clone ID : | 1D12 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Formulation: | Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000 IF 1:200-1:1000 FC 1:200-1:400 ELISA 1:10000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | IL34 |
| Gene ID: | 146433 |
| Uniprot ID: | IL34_HUMAN |
| Specificity: | IL-34 Monoclonal Antibody detects endogenous levels of IL-34 protein. |
| Immunogen: | Purified recombinant fragment of human IL-34 expressed in E. Coli. |
| Function | Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of pro-inflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1. |
| Protein Name | Interleukin-34 Il-34 |
| Database Links | Reactome: R-HSA-449836 Reactome: R-HSA-9680350 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Interleukin-34 antibody Anti-Il-34 antibody Anti-IL34 antibody Anti-C16orf77 antibody |
Information sourced from Uniprot.org