| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-IL22RA1 (16-230) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:100-1:500 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
IL22RA1 |
| Gene ID: |
58985 |
| Uniprot ID: |
I22R1_HUMAN |
| Immunogen Region: |
16-230 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 16-230 of human IL22RA1 (NP_067081.2). |
| Immunogen Sequence: |
HAPEDPSDLLQHVKFQSSNF ENILTWDSGPEGTPDTVYSI EYKTYGERDWVAKKGCQRIT RKSCNLTVETGNLTELYYAR VTAVSAGGRSATKMTDRFSS LQHTTLKPPDVTCISKVRSI QMIVHPTPTPIRAGDGHRLT LEDIFHDLFYHLELQVNRTY QMHLGGKQREYEFFGLTPDT EFLGTIMICVPTWAKESAPY MCRVKTLPDRTWTYS |
| Tissue Specificity | Expressed in colon, liver, lung, pancreas and kidney. No expression in immune cells such as monocytes, T-cells, and NK-cells. Expressed in keratinocytes of normal skin as well as in psoriatic skin lesion. Detected in normal blood brain barrier endothelial cells as well as in multiple sclerosis lesions.Strongly expressed on central nervous system vessels within infiltrated multiple sclerosis lesions. Overexpressed in synovial fluid cells from rheumatoid arthritis and spondyloarthropathy patients. |
| Post Translational Modifications | Ubiquitinated. |
| Function | Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation. |
| Protein Name | Interleukin-22 Receptor Subunit Alpha-1Il-22 Receptor Subunit Alpha-1Il-22r-Alpha-1Il-22ra1Cytokine Receptor Class-Ii Member 9Cytokine Receptor Family 2 Member 9Crf2-9Zcytor11 |
| Database Links | Reactome: R-HSA-8854691 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Interleukin-22 Receptor Subunit Alpha-1 antibodyAnti-Il-22 Receptor Subunit Alpha-1 antibodyAnti-Il-22r-Alpha-1 antibodyAnti-Il-22ra1 antibodyAnti-Cytokine Receptor Class-Ii Member 9 antibodyAnti-Cytokine Receptor Family 2 Member 9 antibodyAnti-Crf2-9 antibodyAnti-Zcytor11 antibodyAnti-IL22RA1 antibodyAnti-IL22R antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
