| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Monoclonal |
| Clone ID: |
SRM |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.09% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:1500-1:6000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
Il22 |
| Gene ID: |
50929 |
| Uniprot ID: |
IL22_MOUSE |
| Immunogen Region: |
34-179 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 34-179 of mouse IL22 (NP_058667.1). |
| Immunogen Sequence: |
LPVNTRCKLEVSNFQQPYIV NRTFMLAKEASLADNNTDVR LIGEKLFRGVSAKDQCYLMK QVLNFTLEDVLLPQSDRFQP YMQEVVPFLTKLSNQLSSCH ISGDDQNIQKNVRRLKETVK KLGESGEIKAIGELDLLFMS LRNACV |
| Function | Cytokine that plays a critical role in modulating tissue responses during inflammation. Plays an essential role in the regeneration of epithelial cells to maintain barrier function after injury and for the prevention of further tissue damage. Unlike most of the cytokines, has no effect on immune cells. Signals through a heterodimeric receptor composed of two subunits, the specific receptor IL22RA1 which is present on non-immune cells in many organs and the shared subunit IL10RB. Ligation of IL22RA1 with IL22 induces activation of the tyrosine kinases JAK1 and TYK2, which in turn activates STAT3. In turn, promotes cell survival and proliferation through STAT3, ERK1/2 and PI3K/AKT pathways. Promotes phosphorylation of GSK3B at 'Ser-9' and CTTN. Promotes epithelial cell spreading. |
| Protein Name | Interleukin-22Il-22Il-10-Related T-Cell-Derived-Inducible FactorIl-TifIl-Tif AlphaInterleukin-22aIl-22a |
| Database Links | Reactome: R-MMU-8854691 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Interleukin-22 antibodyAnti-Il-22 antibodyAnti-Il-10-Related T-Cell-Derived-Inducible Factor antibodyAnti-Il-Tif antibodyAnti-Il-Tif Alpha antibodyAnti-Interleukin-22a antibodyAnti-Il-22a antibodyAnti-Il22 antibodyAnti-Il22a antibodyAnti-Iltif antibodyAnti-Iltifa antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
