Anti-IL21 antibody (25-162 aa) [S5044RM] (STJ11105044)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal Interleukin-21 (25-162 aa) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S5044RM |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:5000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | IL21 |
| Gene ID | 59067 |
| Uniprot ID | IL21_HUMAN |
| Immunogen Region | 25-162 aa |
| Immunogen Sequence | HKSSSQGQDRHMIRMRQLID IVDQLKNYVNDLVPEFLPAP EDVETNCEWSAFSCFQKAQL KSANTGNNERIINVSIKKLK RKPPSTNAGRRQKHRLTCPS CDSYEKKPPKEFLERFKSLL QKMIHQHLSSRTHGSEDS |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 25-162 of human IL21. (NP_068575.1). |
Additional Info
| Tissue Specificity | Expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes. |
| Function | Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. Implicated in the generation and maintenance of T follicular helper (Tfh) cells and the formation of germinal-centers. Together with IL6, control the early generation of Tfh cells and are critical for an effective antibody response to acute viral infection. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation. |
| Protein Name | Interleukin-21Il-21Za11 |
| Database Links | Reactome: R-HSA-9020958 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Interleukin-21 antibodyAnti-Il-21 antibodyAnti-Za11 antibodyAnti-IL21 antibody |
Information sourced from Uniprot.org