• Anti-IL2 antibody [MQ1-17H12] {APC} (STJA0002141)

Anti-IL2 antibody [MQ1-17H12] {APC} (STJA0002141)

SKU:
STJA0002141

£144.50 - £319.50
Current Stock:
Host: Rat
Applications: ICFC
Reactivity: Human
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description: Rat monoclonal antibody anti-Interleukin-2 is suitable for use in IConfocal MicroscopyC research applications.
Clonality: Monoclonal
Clone ID: MQ1-17H12
Conjugation: APC
Isotype: IgG2ak
Formulation: PBS with 0.05% Proclin300, 1% BSA
Storage Instruction: Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product.
Gene Symbol: IL2
Gene ID: 3558
Uniprot ID: IL2_HUMAN
Function Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance. Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5. This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways. Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well. Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production. Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance. Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells.
Protein Name Interleukin-2
Il-2
T-Cell Growth Factor
Tcgf
Aldesleukin
Database Links Reactome: R-HSA-5673001
Reactome: R-HSA-8877330
Reactome: R-HSA-9020558
Reactome: R-HSA-912526
Cellular Localisation Secreted
Alternative Antibody Names Anti-Interleukin-2 antibody
Anti-Il-2 antibody
Anti-T-Cell Growth Factor antibody
Anti-Tcgf antibody
Anti-Aldesleukin antibody
Anti-IL2 antibody

Information sourced from Uniprot.org

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