Anti-IL1RL1/ST2 antibody (Lys19-Phe328) [1A049] (STJA0021752)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenRecombinant Human IL1RL1/ST2 Protein (Lys19-Phe328) [Q01638-2]
General Information
| Short Description | Mouse monoclonal Interleukin-1 Receptor-Like 1 (Lys19-Phe328) antibody for use in ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 1A049 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Protein A/G purified from cell culture supernatant |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks For longer term store at-20°C for up to 12 months |
Target Information
| Gene Symbol | IL1RL1 |
| Gene ID | 9173 |
| Uniprot ID | ILRL1_HUMAN |
| Immunogen | Recombinant Human IL1RL1/ST2 Protein (Lys19-Phe328) [Q01638-2] |
| Immunogen Region | Lys19-Phe328 |
Additional Info
| Post Translational Modifications | Ubiquitinated at Lys-321 in a FBXL19-mediated manner.leading to proteasomal degradation. Ubiquitination by TRAF6 via 'Lys-27'-linked polyubiquitination and deubiquitination by USP38 serves as a critical regulatory mechanism for fine-tuning IL1RL1-mediated inflammatory response. |
| Function | Receptor for interleukin-33 (IL-33) which plays crucial roles in innate and adaptive immunity, contributing to tissue homeostasis and responses to environmental stresses together with coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function (Probable). Upon tissue injury, induces UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages. Isoform B: Inhibits IL-33 signaling. |
| Protein Name | Interleukin-1 Receptor-Like 1Protein St2 |
| Database Links | Reactome: R-HSA-1257604Reactome: R-HSA-6811558Reactome: R-HSA-9014843 Q01638-2 |
| Cellular Localisation | Isoform C: Cell MembraneIsoform B: SecretedCell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Interleukin-1 Receptor-Like 1 antibodyAnti-Protein St2 antibodyAnti-IL1RL1 antibodyAnti-DER4 antibodyAnti-ST2 antibodyAnti-T1 antibody |
Information sourced from Uniprot.org