• Western blot analysis of Mouse lung, using IL-1RAcP antibody (STJ11104791) at1:2000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 60s.
  • Western blot analysis of Rat brain, using IL-1RAcP antibody (STJ11104791) at1:2000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 180s.
  • Western blot analysis of various lysates, using IL-1RAcP antibody (STJ11104791) at1:2000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.

Anti-IL1RAP antibody (391-470) [S4791RM] (STJ11104791)

SKU:
STJ11104791

Shipping:
Free Shipping
Current Stock:
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit monoclonal antibody anti-Interleukin-1 Receptor Accessory Protein (391-470) is suitable for use in Western Blot research applications.
Clonality: Monoclonal
Clone ID: S4791RM
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:1000-1:5000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: IL1RAP
Gene ID: 3556
Uniprot ID: IL1AP_HUMAN
Immunogen Region: 391-470
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 391-470 of human IL-1RAcP (NP_002173.1).
Immunogen Sequence: AHFGTDETILDGKEYDIYVS YARNAEEEEFVLLTLRGVLE NEFGYKLCIFDRDSLPGGIV TDETLSFIQKSRRLLVVLSP
Tissue Specificity Detected in liver, skin, placenta, thymus and lung. Isoform 4 is predominantly expressed in brain. Overexpressed on candidate chronic myeloid leukemia (CML) stem cells, hematopoietic stem cells and mononuclear cells of patients with acute myeloid leukemia (AML). Overexpressed in patients with chronic obstructive pulmonary disease (COPD). Expressed in T-helper 1 (Th1) and T-helper 2 (Th2) cell subsets.
Function Coreceptor for IL1RL2 in the IL-36 signaling system. Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone.binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system. Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD. May play a role in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (Probable). Isoform 2: Associates with secreted ligand-bound IL1R2 and increases the affinity of secreted IL1R2 for IL1B.this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. Enhances the ability of secreted IL1R1 to inhibit IL-33 signaling. Isoform 4: Unable to mediate canonical IL-1 signaling. Required for Src phosphorylation by IL1B. May be involved in IL1B-potentiated NMDA-induced calcium influx in neurons.
Protein Name Interleukin-1 Receptor Accessory Protein
Il-1 Receptor Accessory Protein
Il-1racp
Interleukin-1 Receptor 3
Il-1r-3
Il-1r3
Database Links Reactome: R-HSA-1257604 Q9NPH3-1
Reactome: R-HSA-388844 Q9NPH3-1
Reactome: R-HSA-6811558 Q9NPH3-1
Reactome: R-HSA-9014826 Q9NPH3-1
Reactome: R-HSA-9014843 Q9NPH3-1
Reactome: R-HSA-9020702 Q9NPH3-1
Cellular Localisation Isoform 1: Cell Membrane
Single-Pass Type I Membrane Protein
Isoform 2: Secreted
Isoform 3: Secreted
Alternative Antibody Names Anti-Interleukin-1 Receptor Accessory Protein antibody
Anti-Il-1 Receptor Accessory Protein antibody
Anti-Il-1racp antibody
Anti-Interleukin-1 Receptor 3 antibody
Anti-Il-1r-3 antibody
Anti-Il-1r3 antibody
Anti-IL1RAP antibody
Anti-C3orf13 antibody
Anti-IL1R3 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance