| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit monoclonal antibody anti-Interleukin-18 Receptor 1 (141-320) is suitable for use in Western Blot research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
S4230RM |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
IL18R1 |
| Gene ID: |
8809 |
| Uniprot ID: |
IL18R_HUMAN |
| Immunogen Region: |
141-320 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 141-320 of human IL18R1/IL-18 R alpha (NP_003846.1). |
| Immunogen Sequence: |
ENSYYQTLVNSTSLYKNCKK LLLENNKNPTIKKNAEFEDQ GYYSCVHFLHHNGKLFNITK TFNITIVEDRSNIVPVLLGP KLNHVAVELGKNVRLNCSAL LNEEDVIYWMFGEENGSDPN IHEEKEMRIMTPEGKWHASK VLRIENIGESNLNVLYNCTV ASTGGTDTKSFILVRKADMA |
| Tissue Specificity | Highly expressed in leukocytes, spleen, lung. Also expressed, but at lower levels, in liver, small intestine, colon, prostate, thymus, placenta, and heart. Specifically coexpressed with IL18R1 in Th1 cells. |
| Post Translational Modifications | N-glycosylated. N-linked glycosyl chains contribute to ligand recognition and intra-receptor interactions required for formation of an active ternary receptor complex. |
| Function | Within the IL18 receptor complex, responsible for the binding of the pro-inflammatory cytokine IL18, but not IL1A nor IL1B. Involved in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells. Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3. |
| Protein Name | Interleukin-18 Receptor 1Il-18r-1Il-18r1Cd218 Antigen-Like Family Member ACdw218aIl1 Receptor-Related ProteinIl-1rrpIl1r-RpInterleukin-18 Receptor AlphaIl-18r-AlphaIl-18ralphaCd Antigen Cd218a |
| Database Links | Reactome: R-HSA-9008059Reactome: R-HSA-9012546 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Interleukin-18 Receptor 1 antibodyAnti-Il-18r-1 antibodyAnti-Il-18r1 antibodyAnti-Cd218 Antigen-Like Family Member A antibodyAnti-Cdw218a antibodyAnti-Il1 Receptor-Related Protein antibodyAnti-Il-1rrp antibodyAnti-Il1r-Rp antibodyAnti-Interleukin-18 Receptor Alpha antibodyAnti-Il-18r-Alpha antibodyAnti-Il-18ralpha antibodyAnti-Cd Antigen Cd218a antibodyAnti-IL18R1 antibodyAnti-IL1RRP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Immunofluorescence analysis of PC-12 cells using [KO Validated] KEAP1 Rabbit polyclonal antibody (STJ11104499) at dilution of 1:100 (40x lens). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/177143/368561/STJ11104499_1__57159.1713134043.jpg?c=1 "Immunofluorescence analysis of PC-12 cells using [KO Validated] KEAP1 Rabbit polyclonal antibody (STJ11104499) at dilution of 1:100 (40x lens). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.")