| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:5000IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | IL18BP |
| Gene ID: | 10068 |
| Uniprot ID: | I18BP_HUMAN |
| Immunogen Region: | 31-194 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 31-194 of human IL18BP (NP_001138529.1). |
| Immunogen Sequence: | TPVSQTTTAATASVRSTKDP CPSQPPVFPAAKQCPALEVT WPEVEVPLNGTLSLSCVACS RFPNFSILYWLGNGSFIEHL PGRLWEGSTSRERGSTGTQL CKALVLEQLTPALHSTNFSC VLVDPEQVVQRHVVLAQLWA GLRATLPPTQEALPSSHSSP QQQG |
| Tissue Specificity | Strongly expressed in heart, lung, placenta and spleen. |
| Post Translational Modifications | N- and O-glycosylated. O-glycosylated with core 1-like and core 2-like glycans. O-glycan heterogeneity at Ser-53: HexHexNAc (major) and Hex2HexNAc2 (minor). N-glycan heterogeneity at Asn-103: Hex5HexNAc4 (minor), dHex1Hex5HexNAc4 (major) and Hex6HexNAc5 (minor).N-glycan at Asn-147: dHex1Hex5HexNAc4. |
| Function | Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response. |
| Protein Name | Interleukin-18-Binding ProteinIl-18bpTadekinig-Alfa |
| Database Links | Reactome: R-HSA-9008059Reactome: R-HSA-9012546 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Interleukin-18-Binding Protein antibodyAnti-Il-18bp antibodyAnti-Tadekinig-Alfa antibodyAnti-IL18BP antibody |
Information sourced from Uniprot.org