Anti-IL12RB2 nanobody [SAA1301] (STJN000297)

Anti-IL12RB2 nanobody [SAA1301] (STJN000297)

SKU:
STJN000297
€473.13 - €2,040.63
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Covered by St John's Laboratory Guarantee

Host: Alpaca
Applications: ELISA/FC/SPR
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Alpaca monoclonal nanobody anti-Interleukin-12 Receptor Subunit Beta-2 is suitable for use in ELISA, Flow Cytometry and SPR research applications.
Clonality : Monoclonal
Clone ID : SAA1301
Conjugation: Unconjugated
Isotype: VHH-8His-Cys-tag
Formulation: 0.01M PBS, pH 7.4.
Purification: Purified by Nickel column.
Concentration: 1 mg/mL
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term.
Gene Symbol: IL12RB2
Gene ID: 3595
Uniprot ID: I12R2_HUMAN
Post Translational Modifications On IL12 binding, phosphorylated on C-terminal tyrosine residues by JAK2. Phosphorylation on Tyr-800 is required for STAT4 binding and activation, and for SOCS3 binding.
Function Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production.
Protein Name Interleukin-12 Receptor Subunit Beta-2
Il-12 Receptor Subunit Beta-2
Il-12r Subunit Beta-2
Il-12r-Beta-2
Il-12rb2
Database Links Reactome: R-HSA-8984722
Reactome: R-HSA-9020591
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Nanobody Names Anti-Interleukin-12 Receptor Subunit Beta-2 nanobody
Anti-Il-12 Receptor Subunit Beta-2 nanobody
Anti-Il-12r Subunit Beta-2 nanobody
Anti-Il-12r-Beta-2 nanobody
Anti-Il-12rb2 nanobody
Anti-IL12RB2 nanobody

Information sourced from Uniprot.org

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