| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | IL11RA |
| Gene ID: | 3590 |
| Uniprot ID: | I11RA_HUMAN |
| Immunogen Region: | 30-290 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-290 of human IL11RA (NP_001136256.1). |
| Immunogen Sequence: | WGPPGVQYGQPGRSVKLCCP GVTAGDPVSWFRDGEPKLLQ GPDSGLGHELVLAQADSTDE GTYICQTLDGALGGTVTLQL GYPPARPVVSCQAADYENFS CTWSPSQISGLPTRYLTSYR KKTVLGADSQRRSPSTGPWP CPQDPLGAARCVVHGAEFWS QYRINVTEVNPLGASTRLLD VSLQSILRPDPPQGLRVESV PGYPRRLRASWTYPASWPCQ PHFLLKFRLQYRPAQHPAW |
| Tissue Specificity | Expressed in a number of cell lines, including the myelogenous leukemia cell line K-562, the megakaryocytic leukemia cell line M-07e, the erythroleukemia cell line TF-1, and the osteosarcoma cell lines, MG-63 and SaOS-2. Also expressed in normal and malignant prostate epithelial cell lines. Expression levels are increased in prostate carcinoma. |
| Post Translational Modifications | A short soluble form is also released from the membrane by proteolysis. The sIL11RA is formed either by limited proteolysis of membrane-bound receptors, a process referred to as ectodomain shedding, or directly secreted from the cells after alternative mRNA splicing. mIL11RA is cleaved by the proteases ADAM10, ELANE and PRTN3. |
| Function | Receptor for interleukin-11 (IL11). The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells (Probable). Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number. Soluble interleukin-11 receptor subunit alpha: Soluble form of IL11 receptor (sIL11RA) that acts as an agonist of IL11 activity. The IL11:sIL11RA complex binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL11RA in a process called IL11 trans-signaling. Isoform HCR2: Soluble form of IL11 receptor (sIL11RA) that acts as an agonist of IL11 activity. The IL11:sIL11RA complex binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL11RA in a process called IL11 trans-signaling. |
| Protein Name | Interleukin-11 Receptor Subunit Alpha Il-11 Receptor Subunit Alpha Il-11r Subunit Alpha Il-11r-Alpha Il-11ra Cleaved Into - Soluble Interleukin-11 Receptor Subunit Alpha Sil-11r Sil-11ra Sil11ra |
| Database Links | Reactome: R-HSA-6788467 |
| Cellular Localisation | Interleukin-11 Receptor Subunit Alpha: Membrane Single-Pass Type I Membrane Protein Soluble Interleukin-11 Receptor Subunit Alpha: Secreted Isoform Hcr2: Secreted |
| Alternative Antibody Names | Anti-Interleukin-11 Receptor Subunit Alpha antibody Anti-Il-11 Receptor Subunit Alpha antibody Anti-Il-11r Subunit Alpha antibody Anti-Il-11r-Alpha antibody Anti-Il-11ra Cleaved Into - Soluble Interleukin-11 Receptor Subunit Alpha antibody Anti-Sil-11r antibody Anti-Sil-11ra antibody Anti-Sil11ra antibody Anti-IL11RA antibody |
Information sourced from Uniprot.org