| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-IL10RB (20-220) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
IL10RB |
| Gene ID: |
3588 |
| Uniprot ID: |
I10R2_HUMAN |
| Immunogen Region: |
20-220 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 20-220 of human IL10RB (NP_000619.3). |
| Immunogen Sequence: |
MVPPPENVRMNSVNFKNILQ WESPAFAKGNLTFTAQYLSY RIFQDKCMNTTLTECDFSSL SKYGDHTLRVRAEFADEHSD WVNITFCPVDDTIIGPPGMQ VEVLADSLHMRFLAPKIENE YETWTMKNVYNSWTYNVQYW KNGTDEKFQITPQYDFEVLR NLEPWTTYCVQVRGFLPDRN KAGEWSEPVCEQTTHDETVP S |
| Function | Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. |
| Protein Name | Interleukin-10 Receptor Subunit BetaIl-10 Receptor Subunit BetaIl-10r Subunit BetaIl-10rbCytokine Receptor Class-Ii Member 4Cytokine Receptor Family 2 Member 4Crf2-4Interleukin-10 Receptor Subunit 2Il-10r Subunit 2Il-10r2Cd Antigen Cdw210b |
| Database Links | Reactome: R-HSA-449836Reactome: R-HSA-6783783Reactome: R-HSA-8854691 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Interleukin-10 Receptor Subunit Beta antibodyAnti-Il-10 Receptor Subunit Beta antibodyAnti-Il-10r Subunit Beta antibodyAnti-Il-10rb antibodyAnti-Cytokine Receptor Class-Ii Member 4 antibodyAnti-Cytokine Receptor Family 2 Member 4 antibodyAnti-Crf2-4 antibodyAnti-Interleukin-10 Receptor Subunit 2 antibodyAnti-Il-10r Subunit 2 antibodyAnti-Il-10r2 antibodyAnti-Cd Antigen Cdw210b antibodyAnti-IL10RB antibodyAnti-CRFB4 antibodyAnti-D21S58 antibodyAnti-D21S66 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
