Immunofluorescence analysis of L929 cells using IL10RB Rabbit polyclonal antibody (STJ118126) at dilution of 1:100. Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.

Anti-IL10RB antibody (20-220) (STJ118126)

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STJ118126
£112.50 - £524.50
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Host: Rabbit
Applications: WB/IF/ICC/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
IF/ICC:1:50-1:200
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: IL10RB
Gene ID: 3588
Uniprot ID: I10R2_HUMAN
Immunogen Region: 20-220
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 20-220 of human IL10RB (NP_000619.3).
Immunogen Sequence: MVPPPENVRMNSVNFKNILQ WESPAFAKGNLTFTAQYLSY RIFQDKCMNTTLTECDFSSL SKYGDHTLRVRAEFADEHSD WVNITFCPVDDTIIGPPGMQ VEVLADSLHMRFLAPKIENE YETWTMKNVYNSWTYNVQYW KNGTDEKFQITPQYDFEVLR NLEPWTTYCVQVRGFLPDRN KAGEWSEPVCEQTTHDETVP S
Function Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state.
Protein Name Interleukin-10 Receptor Subunit Beta
Il-10 Receptor Subunit Beta
Il-10r Subunit Beta
Il-10rb
Cytokine Receptor Class-Ii Member 4
Cytokine Receptor Family 2 Member 4
Crf2-4
Interleukin-10 Receptor Subunit 2
Il-10r Subunit 2
Il-10r2
Cd Antigen Cdw210b
Database Links Reactome: R-HSA-449836
Reactome: R-HSA-6783783
Reactome: R-HSA-8854691
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-Interleukin-10 Receptor Subunit Beta antibody
Anti-Il-10 Receptor Subunit Beta antibody
Anti-Il-10r Subunit Beta antibody
Anti-Il-10rb antibody
Anti-Cytokine Receptor Class-Ii Member 4 antibody
Anti-Cytokine Receptor Family 2 Member 4 antibody
Anti-Crf2-4 antibody
Anti-Interleukin-10 Receptor Subunit 2 antibody
Anti-Il-10r Subunit 2 antibody
Anti-Il-10r2 antibody
Anti-Cd Antigen Cdw210b antibody
Anti-IL10RB antibody
Anti-CRFB4 antibody
Anti-D21S58 antibody
Anti-D21S66 antibody

Information sourced from Uniprot.org

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