• Western blot analysis of lysates from COLO cells, using IKZF3 Antibody. The lane on the right is blocked with the synthesized peptide.
  • Western blot analysis of various cells using Ikaros 3 Polyclonal Antibody diluted at 1：1000 cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003, Inventbiotech, MN, USA).

Anti-IKZF3 antibody (361-410 aa) (STJ93664)

SKU:
STJ93664

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Zinc finger protein Aiolos (361-410 aa) is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
ELISA 1:10000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: IKZF3
Gene ID: 22806
Uniprot ID: IKZF3_HUMAN
Immunogen Region: 361-410 aa
Specificity: Ikaros 3 Polyclonal Antibody detects endogenous levels of Ikaros 3 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human IKZF3 at the amino acid range 361-410
Post Translational Modifications Phosphorylation on tyrosine residues induced by IL2 is required for dissociation from HRAS and nuclear translocation of IKZF3 in T-cells. Phosphorylation on tyrosine residues induced by IL4 is required for dissociation from Bcl-X(L) in T-cells.
Function Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner.
Protein Name Zinc Finger Protein Aiolos
Ikaros Family Zinc Finger Protein 3
Cellular Localisation Nucleus
Cytoplasm
Isoform 1: Nucleus
Isoform 3: Nucleus
Isoform 11: Nucleus
Isoform 14: Nucleus
Isoform 12: Cytoplasm
Alternative Antibody Names Anti-Zinc Finger Protein Aiolos antibody
Anti-Ikaros Family Zinc Finger Protein 3 antibody
Anti-IKZF3 antibody
Anti-ZNFN1A3 antibody

Information sourced from Uniprot.org

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