| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:5000IF/ICC:1:100-1:500ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | IKBIP |
| Gene ID: | 121457 |
| Uniprot ID: | IKIP_HUMAN |
| Immunogen Region: | 115-350 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 115-350 of human IKBIP (NP_963906.1). |
| Immunogen Sequence: | IIAHLKRLQEEINEVKTWSN RITEKQDILNNSLTTLSQDI TKVDQSTTSMAKDVGLKITS VKTDIRRISGLVTDVISLTD SVQELENKIEKVEKNTVKNI GDLLSSSIDRTATLRKTASE NSQRINSVKKTLTELKSDFD KHTDRFLSLEGDRAKVLKTV TFANDLKPKVYNLKKDFSRL EPLVNDLTLRIGRLVTDLLQ REKEIAFLSEKISNLTIVQA EIKDIKDEIAHISDMN |
| Tissue Specificity | Expressed in vein endothelial cells. Isoform 4 is expressed in lung, kidney, spleen, thymus and skeletal muscle. |
| Post Translational Modifications | N-glycosylated. Isoform 4 is glycosylated at Asn-154. |
| Function | Target of p53/TP53 with pro-apoptotic function. |
| Protein Name | Inhibitor Of Nuclear Factor Kappa-B Kinase-Interacting ProteinI Kappa-B Kinase-Interacting ProteinIkbkb-Interacting ProteinIkk-Interacting Protein |
| Database Links | Reactome: R-HSA-9758274 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane ProteinIsoform 4 Deletion Of The HydrophobicOr Transmembrane Region Between Aa 45-63 Results In Uniform Distribution Throughout The CellSuggesting That This Region Is Responsible For Endoplasmic Reticulum Localization |
| Alternative Antibody Names | Anti-Inhibitor Of Nuclear Factor Kappa-B Kinase-Interacting Protein antibodyAnti-I Kappa-B Kinase-Interacting Protein antibodyAnti-Ikbkb-Interacting Protein antibodyAnti-Ikk-Interacting Protein antibodyAnti-IKBIP antibodyAnti-IKIP antibody |
Information sourced from Uniprot.org
