| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-IK (1-280) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
IK |
| Gene ID: |
3550 |
| Uniprot ID: |
RED_HUMAN |
| Immunogen Region: |
1-280 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human IK (NP_006074.2). |
| Immunogen Sequence: |
MPERDSEPFSNPLAPDGHDV DDPHSFHQSKLTNEDFRKLL MTPRAAPTSAPPSKSRHHEM PREYNEDEDPAARRRKKKSY YAKLRQQEIERERELAEKYR DRAKERRDGVNKDYEETELI STTANYRAVGPTAEADKSAA EKRRQLIQESKFLGGDMEHT HLVKGLDFALLQKVRAEIAS KEKEEEELMEKPQKETKKDE DPENKIEFKTRLGRNVYRML FKSKAYERNELFLPGRMAY |
| Tissue Specificity | Ubiquitous. |
| Function | Involved in pre-mRNA splicing as a component of the spliceosome. Auxiliary spliceosomal protein that regulates selection of alternative splice sites in a small set of target pre-mRNA species (Probable). Required for normal mitotic cell cycle progression. Recruits MAD1L1 and MAD2L1 to kinetochores, and is required to trigger the spindle assembly checkpoint. Required for normal accumulation of SMU1. (Microbial infection) Required, together with SMU1, for normal splicing of influenza A virus NS1 pre-mRNA, which is required for the production of the exportin NS2 and for the production of influenza A virus particles. Not required for the production of VSV virus particles. |
| Protein Name | Protein RedCytokine IkIk FactorProtein Rer |
| Database Links | Reactome: R-HSA-72163 |
| Cellular Localisation | NucleusNucleoplasmChromosomeCytoplasmCytoskeletonSpindle PolePredominantly Present Throughout The Nucleoplasm During PrometaphaseMetaphase And AnaphaseIs Also Detected In Nuclear Foci That Are Not Identical With Cajal BodiesStarts To Accumulate At Chromosomes During TelophaseAnd Is Nearly Exclusively Associated With Chromosomes In Newly Divided CellsColocalizes With Mad1l1 At Mitotic Spindle Poles During Metaphase And Anaphase |
| Alternative Antibody Names | Anti-Protein Red antibodyAnti-Cytokine Ik antibodyAnti-Ik Factor antibodyAnti-Protein Rer antibodyAnti-IK antibodyAnti-RED antibodyAnti-RER antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
