| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
Iigp1 |
| Gene ID: |
60440 |
| Uniprot ID: |
IIGP1_MOUSE |
| Immunogen Region: |
150-250 aa |
| Specificity: |
A synthetic peptide corresponding to a sequence within amino acids 150-250 of mouse Iigp1 (NP_068564.4). |
| Immunogen Sequence: |
DFFIIISATRFKKNDIDIAK AISMMKKEFYFVRTKVDSDI TNEADGKPQTFDKEKVLQDI RLNCVNTFRENGIAEPPIFL LSNKNVCHYDFPVLMDKLIS D |
| Function | GTPase with low activity. Has higher affinity for GDP than for GTP. Plays a role in resistance to intracellular pathogens. Required for disruption of the parasitophorous vacuole formed following T.gondii infection and subsequent killing of the parasite. Mediates resistance to C.trachomatis infection by targeting bacterial inclusions to autophagosomes for subsequent lysosomal destruction. |
| Protein Name | Interferon-Inducible Gtpase 1 |
| Cellular Localisation | CytoplasmNucleus MembranePeripheral Membrane ProteinEndoplasmic Reticulum MembraneGolgi ApparatusGolgi Stack MembraneParasitophorous Vacuole MembraneLocalizes To The Bacterial Inclusions Formed Following CTrachomatis InfectionAccumulates In A Gtp-Bound Form On The Parasitophorous Vacuole Membranes Formed Following TGondii Infection But Exists In A Gdp-Bound Form In Uninfected Cells |
| Alternative Antibody Names | Anti-Interferon-Inducible Gtpase 1 antibodyAnti-Iigp1 antibodyAnti-Irga6 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
