| Function | GTPase with low activity. Has higher affinity for GDP than for GTP. Plays a role in resistance to intracellular pathogens. Required for disruption of the parasitophorous vacuole formed following T.gondii infection and subsequent killing of the parasite. Mediates resistance to C.trachomatis infection by targeting bacterial inclusions to autophagosomes for subsequent lysosomal destruction. |
| Protein Name | Interferon-Inducible Gtpase 1 |
| Cellular Localisation | CytoplasmNucleus MembranePeripheral Membrane ProteinEndoplasmic Reticulum MembraneGolgi ApparatusGolgi Stack MembraneParasitophorous Vacuole MembraneLocalizes To The Bacterial Inclusions Formed Following CTrachomatis InfectionAccumulates In A Gtp-Bound Form On The Parasitophorous Vacuole Membranes Formed Following TGondii Infection But Exists In A Gdp-Bound Form In Uninfected Cells |
| Alternative Antibody Names | Anti-Interferon-Inducible Gtpase 1 antibodyAnti-Iigp1 antibodyAnti-Irga6 antibody |
Information sourced from Uniprot.org
