| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Immunoglobulin superfamily member 8 (451-500 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000ELISA 1:20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
IGSF8 |
| Gene ID: |
93185 |
| Uniprot ID: |
IGSF8_HUMAN |
| Immunogen Region: |
451-500 aa |
| Specificity: |
CD316 Polyclonal Antibody detects endogenous levels of CD316 protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the Internal region of human IGSF8 at the amino acid range 451-500 |
| Function | Member of the immunoglobulin superfamily (IgSF) that links tetraspanin-enriched microdomains to the actin cytoskeleton and plays several important roles in innate and adaptive immunity. Acts as an inducible receptor of HSPA8 on dendritic cells to enhance the CCL21/SLC-dependent migration of activated mature dendritic cells while attenuating their antigen-specific stimulatory capacities. In complex with alpha-actinins ACTN1 and ACTN4, regulates actin dynamics in the immune synapse and subsequent T-cell activation. Inhibits the entry of several viruses such as hepatitis C Virus (HCV) or HIV-1. Mechanistically, promotes a change in CD81 organization at the plasma membrane by significantly restricting its diffusion which in turn influences CD81 interaction with Claudin-1/CLDN1, preventing CLDN1 from acting as a co-receptor required for HCV entry. Accumulates at the presynaptic terminal, the producer cell side of the virological synapse, to prevent HIV-1 Env-mediated cell-cell fusion. Highly expressed on malignant cells with antigen presentation defects, interacts with NK receptor KIR3DL2 to suppress NK-cell cytotoxicity. May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain. |
| Protein Name | Immunoglobulin Superfamily Member 8Igsf8Cd81 Partner 3Glu-Trp-Ile Ewi Motif-Containing Protein 2Ewi-2Keratinocytes-Associated Transmembrane Protein 4Kct-4Lir-D1Prostaglandin Regulatory-Like ProteinPgrlCd Antigen Cd316 |
| Cellular Localisation | Cell MembraneSingle-Pass Membrane ProteinColocalizes With Cd81 At The Immune Synapse |
| Alternative Antibody Names | Anti-Immunoglobulin Superfamily Member 8 antibodyAnti-Igsf8 antibodyAnti-Cd81 Partner 3 antibodyAnti-Glu-Trp-Ile Ewi Motif-Containing Protein 2 antibodyAnti-Ewi-2 antibodyAnti-Keratinocytes-Associated Transmembrane Protein 4 antibodyAnti-Kct-4 antibodyAnti-Lir-D1 antibodyAnti-Prostaglandin Regulatory-Like Protein antibodyAnti-Pgrl antibodyAnti-Cd Antigen Cd316 antibodyAnti-IGSF8 antibodyAnti-CD81P3 antibodyAnti-EWI2 antibodyAnti-KCT4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
