Anti-IGHA1 antibody (99-353 aa) [S5143RM] (STJ11105143)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal Immunoglobulin Heavy Constant Alpha 1 (99-353 aa) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S5143RM |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | IGHA1Uniprot ID=IGHA1_HUMAN" |
| Immunogen Region | 99-353 aa |
| Immunogen Sequence | VPCPVPSTPPTPSPSTPPTP SPSCCHPRLSLHRPALEDLL LGSEANLTCTLTGLRDASGV TFTWTPSSGKSAVQGPPERD LCGCYSVSSVLPGCAEPWNH GKTFTCTAAYPESKTPLTAT LSKSGNTFRPEVHLLPPPSE ELALNELVTLTCLARGFSPK DVLVRWLQGSQELPREKYLT WASRQEPSQGTTTFAVTSIL RVAAEDWKKGDTFSCMVGHE ALPLAFTQKTIDRLADWQM |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 99-353 of human IgA1. (P01876). |
Additional Info
| Function | Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens. The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen. Ig alpha is the major immunoglobulin class in body secretions. |
| Protein Name | Immunoglobulin Heavy Constant Alpha 1Ig Alpha-1 Chain C RegionIg Alpha-1 Chain C Region BurIg Alpha-1 Chain C Region Tro |
| Cellular Localisation | Isoform 1: SecretedIsoform 2: Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Immunoglobulin Heavy Constant Alpha 1 antibodyAnti-Ig Alpha-1 Chain C Region antibodyAnti-Ig Alpha-1 Chain C Region Bur antibodyAnti-Ig Alpha-1 Chain C Region Tro antibodyAnti-IGHA1 antibody |
Information sourced from Uniprot.org