| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
IGFBP1 |
| Gene ID: |
3484 |
| Uniprot ID: |
IBP1_HUMAN |
| Immunogen Region: |
81-259 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 81-259 of human IGFBP1 (NP_000587.1). |
| Immunogen Sequence: |
GLSCRALPGEQQPLHALTRG QGACVQESDASAPHAAEAGS PESPESTEITEEELLDNFHL MAPSEEDHSILWDAISTYDG SKALHVTNIKKWKEPCRIEL YRVVESLAKAQETSGEEISK FYLPNCNKNGFYHSRQCETS MDGEAGLCWCVYPWNGKRIP GSPEIRGDPNCQIYFNVQN |
| Post Translational Modifications | Phosphorylated.probably by casein kinase II. Phosphorylation alters the affinity of the protein for IGFs. In amniotic fluid, the unmodified protein is the most abundant form, while mono-, bi-, tri- and tetraphosphorylated forms are present in decreasing amounts. The phosphorylation state may influence the propensity to proteolysis. |
| Function | Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including cell migration, proliferation, differentiation or apoptosis in a cell-type specific manner. Plays also a positive role in cell migration by interacting with integrin ITGA5:ITGB1 through its RGD motif. Mechanistically, binding to integrins leads to activation of focal adhesion kinase/PTK2 and stimulation of the mitogen-activated protein kinase (MAPK) pathway. Regulates cardiomyocyte apoptosis by suppressing HIF-1alpha/HIF1A ubiquitination and subsequent degradation. |
| Protein Name | Insulin-Like Growth Factor-Binding Protein 1Ibp-1Igf-Binding Protein 1Igfbp-1Placental Protein 12Pp12 |
| Database Links | Reactome: R-HSA-380994Reactome: R-HSA-381426Reactome: R-HSA-8957275Reactome: R-HSA-9615017 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Insulin-Like Growth Factor-Binding Protein 1 antibodyAnti-Ibp-1 antibodyAnti-Igf-Binding Protein 1 antibodyAnti-Igfbp-1 antibodyAnti-Placental Protein 12 antibodyAnti-Pp12 antibodyAnti-IGFBP1 antibodyAnti-IBP1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
